Scientist - Protein Expression and Bio-Process Development from Alpha Consulting Corp. San Diegp, CA 92121
SCIENTIST - PROTEIN EXPRESSION AND BIO-PROCESS DEVELOPMENTSAN DIEGO, CA Project Description:
We are seeking a scientist with a strong interest in protein expression and bioprocess development to join the protein science group in the Discovery Biotherapeutics department at our new state-of-the art facility in San Diego, CA.
The qualified candidate will be responsible for mammalian protein expression and bioprocess development in both shake flasks and automated mini-bioreactors, and other lab related activities as assigned.
Key hands-on experience and requirements for this position:
Expression of antibodiesExperience with operating Ambr mini-bioreactor and bench scale bioreactorExperience with mammalian cell (CHO, HEK) culture, transient and stable transfectionResponsibilities will include, but are not limited to, the following:
Expression of antibodies (bi-/multi-specific antibodies) and other recombinant proteins in transient and stable formats to support biotherapeutic drug discovery projects.
Mammalian cell culturing in both shake flasks and automated mini bioreactors, along with HT automated liquid handling systems.
Process development and optimization for batch and fed-batch bioreactor and shake flask expressions.
Transient protein expression as well as stable pool and single cell cloning generation.
Purification and biophysical characterization of analytical scale expression samples.
Ensure accurate registration of protein expression samples and associated data into electronic inventory system and electronic laboratory notebook.
Additional Job Requirements:
Position Handles Hazardous Materials Required Skills:
Bachelor's degree with at least 4-6 years' work experience or master's degree in Biology, Biochemistry, Bioengineering with at least 2-4 years' work experience in an industry setting.
Hands on experience with mammalian cell (CHO, HEK) culture, transient and stable transfection and protein characterization.
Experience with operating Ambr mini-bioreactor and bench scale bioreactor, HT automation and analysis, bioprocess development and process optimization are highly desirable.
Proficiency with Design of experiment (DOE) and DOE analysis software will be a plus.
Working knowledge and familiar with protein and antibody purification and analytical assessment.
Excellent data management skills and a demonstrated ability to manage large structure datasets using.
Excellent written and oral communication skills including ability to present scientific data in group setting.
Excellent organization to multi-task and manage multiple projects.
Functional/Scientific/Technical Skills:
Implement and validate protocols.
Mastery of basic lab skills.
Reviewing literature for technical support.
Data analysis.
Familiarity with data retrieval and input from database.
This 12
month position starts ASAP.
Please E-MAIL your resume (attachment to email) with rate and availability to Karen:
karen@alphaconsulting.
com ALPHA'S REQUIREMENT #21-00862W2 ONLY MUST BE ELIGIBLE TO WORK IN THE U.
S.
AS AN HOURLY W2 EMPLOYEE.
Estimated Salary: $20 to $28 per hour based on qualifications.
We are seeking a scientist with a strong interest in protein expression and bioprocess development to join the protein science group in the Discovery Biotherapeutics department at our new state-of-the art facility in San Diego, CA.
The qualified candidate will be responsible for mammalian protein expression and bioprocess development in both shake flasks and automated mini-bioreactors, and other lab related activities as assigned.
Key hands-on experience and requirements for this position:
Expression of antibodiesExperience with operating Ambr mini-bioreactor and bench scale bioreactorExperience with mammalian cell (CHO, HEK) culture, transient and stable transfectionResponsibilities will include, but are not limited to, the following:
Expression of antibodies (bi-/multi-specific antibodies) and other recombinant proteins in transient and stable formats to support biotherapeutic drug discovery projects.
Mammalian cell culturing in both shake flasks and automated mini bioreactors, along with HT automated liquid handling systems.
Process development and optimization for batch and fed-batch bioreactor and shake flask expressions.
Transient protein expression as well as stable pool and single cell cloning generation.
Purification and biophysical characterization of analytical scale expression samples.
Ensure accurate registration of protein expression samples and associated data into electronic inventory system and electronic laboratory notebook.
Additional Job Requirements:
Position Handles Hazardous Materials Required Skills:
Bachelor's degree with at least 4-6 years' work experience or master's degree in Biology, Biochemistry, Bioengineering with at least 2-4 years' work experience in an industry setting.
Hands on experience with mammalian cell (CHO, HEK) culture, transient and stable transfection and protein characterization.
Experience with operating Ambr mini-bioreactor and bench scale bioreactor, HT automation and analysis, bioprocess development and process optimization are highly desirable.
Proficiency with Design of experiment (DOE) and DOE analysis software will be a plus.
Working knowledge and familiar with protein and antibody purification and analytical assessment.
Excellent data management skills and a demonstrated ability to manage large structure datasets using.
Excellent written and oral communication skills including ability to present scientific data in group setting.
Excellent organization to multi-task and manage multiple projects.
Functional/Scientific/Technical Skills:
Implement and validate protocols.
Mastery of basic lab skills.
Reviewing literature for technical support.
Data analysis.
Familiarity with data retrieval and input from database.
This 12
month position starts ASAP.
Please E-MAIL your resume (attachment to email) with rate and availability to Karen:
karen@alphaconsulting.
com ALPHA'S REQUIREMENT #21-00862W2 ONLY MUST BE ELIGIBLE TO WORK IN THE U.
S.
AS AN HOURLY W2 EMPLOYEE.
Estimated Salary: $20 to $28 per hour based on qualifications.
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